Evaluating the Use of Large-dose, Extended Interval Vancomycin Intravenous Administration for Skin and Soft Tissue Infections

Completed 4 enrolled Fraser Health

RandomizedParallel-groupOpen-labelTreatment

Summary

Our hypothesis is that large-dose, extended-interval vancomycin (30 mg/kg IV q24h) administration provides non-inferior clinical efficacy and microbiological efficacy to standard vancomycin (15 mg/kg IV q12h) administration for skin and soft tissue infections in an outpatient setting.

Timeline

Start: 2010-03
Primary completion: 2010-09
Completion: 2010-09

Publications

Results Cohen E, Dadashev A, Drucker M, Samra Z, Rubinstein E, Garty M. Once-daily versus twice-daily intravenous administration of vancomycin for infections in hospitalized patients. J Antimicrob Chemother. 2002 Jan;49(1):155-60. doi: 10.1093/jac/49.1.155.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Vancomycin	Other / unclassified	15 mg/kg	Intravenous
Comparator	Vancomycin	Other / unclassified	30 mg/kg	Intravenous

Indications

No indication recorded.