Safety and Effectiveness of Artemisinin-based Combination Therapies (ACTs) With Repeated Treatments for Uncomplicated Falciparum Malaria Over a Three-year Period

Phase 4 Unknown 1200 enrolled Liverpool School of Tropical Medicine Malawi-Liverpool-Wellcome Trust Clinical Research Programme · collab National Malaria Control Programme, Malawi · collab Research for Equity and Community Health Trust · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

A community-based, open-label, cluster-randomised longitudinal study in which children are randomized according to village health worker catchment areas comparing the safety and effectiveness of repeated treatments with artemether-lumefantrine (AL) over a 3-year period in children 4-48 months to that of repeated treatment with dihydroartemisinin-piperaquine (DHA-PPQ).

Timeline

Start: 2010-10
Primary completion: 2013-09
Completion: 2013-09

Publications

Roca-Feltrer A, Lalloo DG, Phiri K, Terlouw DJ. Rolling Malaria Indicator Surveys (rMIS): a potential district-level malaria monitoring and evaluation (M&E) tool for program managers. Am J Trop Med Hyg. 2012 Jan;86(1):96-8. doi: 10.4269/ajtmh.2012.11-0397.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Artemether	Small molecule	—	—
Subject	lumefantrine	Small molecule	—	—

Safety and Effectiveness of Artemisinin-based Combination Therapies (ACTs) With Repeated Treatments for Uncomplicated Falciparum Malaria Over a Three-year Period

Summary

Timeline

Publications

Drugs

Indications