Trial of Methyl B12 on Behavioral and Metabolic Measures in Children With Autism

Phase 2/3 Completed 57 enrolled University of California, San Francisco Arkansas Children's Hospital Research Institute · collab University of California, Davis · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

The purpose of this study is to determine whether the supplement Methyl B12 is effective in treating some of the symptoms of Autism.

Timeline

Start: 2010-01
Primary completion: 2013-10
Completion: 2013-11

Outcome

Met primary endpoint

paper the methyl B12 group (2.4) than in the placebo group (3.1) (0.7 greater improvement in the methyl B12 group, 95% CI 1.2-0.2, p = 0.005). PMID 26889605 ↗

Publications

Hendren RL, James SJ, Widjaja F, Lawton B, Rosenblatt A, Bent S. Randomized, Placebo-Controlled Trial of Methyl B12 for Children with Autism. J Child Adolesc Psychopharmacol. 2016 Nov;26(9):774-783. doi: 10.1089/cap.2015.0159. Epub 2016 Feb 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	methylcobalamin	Small molecule	75 ug/kg	Subcutaneous