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drugset / Trial / NCT01041066

Nicardipine Versus Labetalol During Intubation

NCT01041066 ↗

Unknown 70 enrolled Seoul National University Bundang Hospital

RandomizedParallel-groupDouble-blindPrevention

Summary

The aim of this study was to compare the efficacy of nicardipine and labetalol in attenuation of cardiovascular responses to endotracheal intubation.

Timeline

Start: 2009-09
Primary completion: 2009-12
Completion: —

Publications

Ryu JH, Apfel CC, Whelan R, Jeon YT, Hwang JW, Do SH, Ro YJ, Kim CS. Comparative prophylactic and therapeutic effects of intravenous labetalol 0.4 mg/kg and nicardipine 20 mug/kg on hypertensive responses to endotracheal intubation in patients undergoing elective surgeries with general anesthesia: a prospective, randomized, double-blind study. Clin Ther. 2012 Mar;34(3):593-604. doi: 10.1016/j.clinthera.2012.01.017. Epub 2012 Feb 24.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Labetalol	Small molecule	0.4 mg/kg	Intravenous
Comparator	Nicardipine	Small molecule	20 ug/kg	Intravenous

Indications

No indication recorded.