drugset / Trial / NCT01048697
Effect of Weight and/or Obesity on Ethambutol Drug Concentrations
Phase 4
Completed
18 enrolled
Texas Tech University Health Sciences Center
National Center for Research Resources (NCRR) · collabUniversity of Texas Southwestern Medical Center · collab
NaSingle-groupOpen-label
Summary
This study is designed to measure drug concentrations in the blood of healthy volunteers administered a single dose of ethambutol. Our hypothesis is that volunteers with a body mass index (BMI) 25-40 kg/m2 will remove ethambutol more quickly from the blood than leaner volunteers, and those with a BMI \> 40 kg/m2 will have even greater clearance than those who are leaner.
Timeline
- Start
- 2010-01
- Primary completion
- 2010-12
- Completion
- 2010-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ethambutol | Small molecule | 800 mg | Oral |
| Subject | Ethambutol | Small molecule | 1200 mg | Oral |
| Subject | Ethambutol | Small molecule | 1600 mg | Oral |