Interaction of Apelin and Angiotensin in the Systemic Circulation

Completed 12 enrolled University of Edinburgh

RandomizedCrossoverDouble-blindBasic science

Summary

The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease. Apelin improves that pumping ability of the heart and we wish to know if this action persists in the presence of increased levels of angiotensin II.

Timeline

Start: 2010-01
Primary completion: 2010-04
Completion: 2010-04

Publications

Barnes GD, Alam S, Carter G, Pedersen CM, Lee KM, Hubbard TJ, Veitch S, Jeong H, White A, Cruden NL, Huson L, Japp AG, Newby DE. Sustained cardiovascular actions of APJ agonism during renin-angiotensin system activation and in patients with heart failure. Circ Heart Fail. 2013 May;6(3):482-91. doi: 10.1161/CIRCHEARTFAILURE.111.000077. Epub 2013 Mar 21.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Angiotensin II	Peptide	0.5 ug/kg	—

Indications

No indication recorded.