Lipoic Acid and Omega-3 Fatty Acids for Alzheimer's Disease
Summary
The purpose of this study was to see if taking lipoic acid plus omega-3 fatty acids (omega-3s) can slow the Alzheimer's disease (AD) process. To see if the treatment can slow the AD process, the investigators looked at changes in memory and changes in a person's daily activities over 18 months.
Timeline
- Start
- 2010-09
- Primary completion
- 2014-12
- Completion
- 2014-12
Outcome
Missed primary endpoint
registry Lipoic Acid and Omega-3 Fatty Acids vs Placebo; p = 0.82; Mean Difference (Net) -0.42 (95% CI -3.97 to 3.13) NCT01058941 ↗
registry MEAN Lipoic Acid and Omega-3 Fatty Acids: 6.61 (Standard Deviation 6.67) units on a scale NCT01058941 ↗
registry MEAN Placebo: 3.40 (Standard Deviation 4.50) units on a scale NCT01058941 ↗
registry Lipoic Acid and Omega-3 Fatty Acids vs Placebo; p = 0.001; Mean Difference (Net) -3.68 (95% CI -5.90 to -1.46) NCT01058941 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Fish oil concentrate | Unknown | 3 g | Oral |
| Subject | lipoic acid | Unknown | 600 mg | Oral |