drugset / Trial / NCT01070940
L-NMMA Dose-response Study in Healthy Subjects
RandomizedCrossoverSingle-blind
Summary
The purpose of this study is to investigate the effect of different levels of nitric oxide inhibition on blood pressure and arterial stiffness in healthy subjects. L-NMMA, an inhibitor of the nitric oxide synthase, is administered as bolus injection followed by continuous infusion, and is expected to raise blood pressure and arterial stiffness according to L-NMMA dose.
Timeline
- Start
- 2010-02
- Primary completion
- 2010-06
- Completion
- 2010-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | NG-monomethyl-L-arginine (L-NMMA) | Unknown | 2 mg/kg | Intravenous |
| Comparator | NG-monomethyl-L-arginine (L-NMMA) | Unknown | 3 mg/kg | Intravenous |
| Comparator | NG-monomethyl-L-arginine (L-NMMA) | Unknown | 4 mg/kg | Intravenous |
Indications
No indication recorded.