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drugset / Trial / NCT01078779

The Chloroquine for Influenza Prevention Trial

NCT01078779 ↗

Phase 2 Unknown 1516 enrolled National University Hospital, Singapore

RandomizedParallel-groupQuadruple-blindPrevention

Summary

A randomised controlled trial to determine the efficacy of chloroquine for the prevention of influenza

Timeline

Start: 2009-11
Primary completion: 2010-05
Completion: 2010-08

Outcome

Missed primary endpoint

paper relative risk 1·53, 95% CI 0·63-3·72; p=0·376 PMID 21550310 ↗

paper chloroquine does not prevent infection with influenza. PMID 21550310 ↗

Publications

Paton NI, Lee L, Xu Y, Ooi EE, Cheung YB, Archuleta S, Wong G, Wilder-Smith A. Chloroquine for influenza prevention: a randomised, double-blind, placebo controlled trial. Lancet Infect Dis. 2011 Sep;11(9):677-83. doi: 10.1016/S1473-3099(11)70065-2. Epub 2011 May 5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Chloroquine	Small molecule	500 mg	—

Indications