Nicotine Patch Trial in Syrian Primary Care Settings

Phase 2 Completed 269 enrolled University of Memphis

RandomizedParallel-groupTriple-blindTreatment

Summary

The study is a two-arm, parallel group, randomized, placebo-controlled, double blind trial, conducted at four primary health care centers in Aleppo, Syria, to test the efficacy of transdermal nicotine patch therapy vs. placebo patch therapy, when delivered with behavioral counseling, on smoking cessation rates.

Timeline

Start: 2006-08
Primary completion: 2009-07
Completion: 2009-07

Outcome

Missed primary endpoint

paper FINDINGS: Treatment adherence was excellent and nicotine patch produced expected reductions in urges to smoke and withdrawal symptoms, but no treatment effect was observed. PMID 22882805 ↗

Publications

Ward KD, Asfar T, Al Ali R, Rastam S, Weg MW, Eissenberg T, Maziak W. Randomized trial of the effectiveness of combined behavioral/pharmacological smoking cessation treatment in Syrian primary care clinics. Addiction. 2013 Feb;108(2):394-403. doi: 10.1111/j.1360-0443.2012.04048.x. Epub 2012 Nov 19.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Nicotine	Unknown	7 mg	Other

Indications

No indication recorded.