drugset / Trial / NCT01085786
Sequential and Hybrid Therapies for H Pylori Infection
Phase 4
Completed
240 enrolled
Kaohsiung Veterans General Hospital.
Baylor College of Medicine · collabKaohsiung Medical University · collab
RandomizedParallel-groupSingle-blindTreatment
Summary
Primary: To evaluate efficacy of 14 day 2-phase sequential therapy given in two forms. One in which the first component consists of a proton pump inhibitor and amoxicillin given for 7 days followed by the PPI, clarithromycin and metronidazole for 7 days. The alternate will be similar with the exception that the amoxicillin will be continued throughout the 14 days. The secondary endpoint is to evaluate the effectiveness of therapy in relation to antibiotic resistance.
Timeline
- Start
- 2008-08
- Primary completion
- 2010-05
- Completion
- 2010-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Amoxicillin | Other / unclassified | 1 g | — |
| Comparator | Clarithromycin | Small molecule | 500 mg | — |
| Comparator | Esomeprazole | Small molecule | 40 mg | — |
| Comparator | Metronidazole | Small molecule | 500 mg | — |