D-Cycloserine and Social Skills Training in Autism Spectrum Disorders
Summary
The purpose of this study is to determine the effectiveness of D-cycloserine for improving social impairment in child with pervasive developmental disorders (PDD).
Timeline
- Start
- 2010-03
- Primary completion
- 2014-01
- Completion
- 2014-01
Outcome
Mixed primary results
registry MEAN D-cycloserine: -13.39 (Standard Deviation 16.81) units on a scale NCT01086475 ↗
registry MEAN Placebo: -17.00 (Standard Deviation 21.33) units on a scale NCT01086475 ↗
registry D-cycloserine vs Placebo; p = 0.45; t-test, 2 sided NCT01086475 ↗
registry MEAN D-cycloserine: 83.5 (Standard Deviation 2.3) units on a scale NCT01086475 ↗
registry MEAN Placebo: 89.2 (Standard Deviation 2.5) units on a scale NCT01086475 ↗
registry D-cycloserine vs Placebo; p = 0.048; t-test, 2 sided NCT01086475 ↗
Publications
- Iffland M, Livingstone N, Jorgensen M, Hazell P, Gillies D. Pharmacological intervention for irritability, aggression, and self-injury in autism spectrum disorder (ASD). Cochrane Database Syst Rev. 2023 Oct 9;10(10):CD011769. doi: 10.1002/14651858.CD011769.pub2.
- Aye SZ, Ni H, Sein HH, Mon ST, Zheng Q, Wong YKY. The effectiveness and adverse effects of D-cycloserine compared with placebo on social and communication skills in individuals with autism spectrum disorder. Cochrane Database Syst Rev. 2021 Feb 14;2(2):CD013457. doi: 10.1002/14651858.CD013457.pub2.
- Wink LK, Minshawi NF, Shaffer RC, Plawecki MH, Posey DJ, Horn PS, Adams R, Pedapati EV, Schaefer TL, McDougle CJ, Swiezy NB, Erickson CA. d-Cycloserine enhances durability of social skills training in autism spectrum disorder. Mol Autism. 2017 Jan 25;8:2. doi: 10.1186/s13229-017-0116-1. eCollection 2017.
- Minshawi NF, Wink LK, Shaffer R, Plawecki MH, Posey DJ, Liu H, Hurwitz S, McDougle CJ, Swiezy NB, Erickson CA. A randomized, placebo-controlled trial of D-cycloserine for the enhancement of social skills training in autism spectrum disorders. Mol Autism. 2016 Jan 14;7:2. doi: 10.1186/s13229-015-0062-8. eCollection 2016.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cycloserine | Small molecule | 50 mg | — |