drugset / Trial / NCT01087879
The Effect of Hormonal Contraceptives on Androgens and Glucose Metabolism
RandomizedSingle-groupOpen-labelTreatment
Summary
The impact of different administration routes of hormonal contraceptives on androgen secretion, glucose metabolism and inflammation. A prospective randomized trial. The investigators assume, that transdermal or transvaginal hormonal contraception would have less effects on androgen levels, glucose metabolism and inflammatory markers than oral contraceptives.
Timeline
- Start
- 2007-10
- Primary completion
- 2011-01
- Completion
- 2011-01
Publications
- Kallio S, Puurunen J, Ruokonen A, Vaskivuo T, Piltonen T, Tapanainen JS. Antimullerian hormone levels decrease in women using combined contraception independently of administration route. Fertil Steril. 2013 Apr;99(5):1305-10. doi: 10.1016/j.fertnstert.2012.11.034. Epub 2012 Dec 20.
- Piltonen T, Puurunen J, Hedberg P, Ruokonen A, Mutt SJ, Herzig KH, Nissinen A, Morin-Papunen L, Tapanainen JS. Oral, transdermal and vaginal combined contraceptives induce an increase in markers of chronic inflammation and impair insulin sensitivity in young healthy normal-weight women: a randomized study. Hum Reprod. 2012 Oct;27(10):3046-56. doi: 10.1093/humrep/des225. Epub 2012 Jul 18.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Desogestrel | Small molecule | 0.15 mg | Oral |
| Comparator | Etonogestrel | Unknown | 0.12 mg | Other |
| Comparator | ethinyl estradiol | Small molecule | 0.015 mg | Oral |
| Comparator | ethinyl estradiol | Small molecule | 0.02 mg | Oral |
| Comparator | ethinyl estradiol | Small molecule | 0.0339 mg | Oral |
| Comparator | norelgestromin | Unknown | 0.203 mg | Other |
Indications
No indication recorded.