drugset

drugset / Trial / NCT01088009

Efficacy Optimizing Research of Lamivudine Therapy

NCT01088009 ↗

Phase 4 Completed 366 enrolled Nanfang Hospital, Southern Medical University GlaxoSmithKline · collab Major Science and Technology Special Project of China Eleventh Five-year · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to compare the adefovir early add-on to rescue therapy strategy, and also explore the efficacy of Lamivudine and adefovir de-novo combination therapy.

Timeline

Start: 2010-03
Primary completion: 2013-02
Completion: 2013-05

Publications

Xiang KH, Michailidis E, Ding H, Peng YQ, Su MZ, Li Y, Liu XE, Dao Thi VL, Wu XF, Schneider WM, Rice CM, Zhuang H, Li T. Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA. J Hepatol. 2017 Feb;66(2):288-296. doi: 10.1016/j.jhep.2016.09.005. Epub 2016 Sep 17.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Adefovir	Unknown	10 mg	Oral
Comparator	Lamivudine	Other / unclassified	100 mg	Oral

Indications