Nitric Oxide Therapy for Acute Chest Syndrome in Sickle Cell Disease Children

Summary

Acute chest syndrome is a severe sickle cell disease complication in children requiring blood transfusion therapy to prevent acute respiratory failure and death. Nitric oxide is a potent vasodilator that could reverse pulmonary vascular occlusion and restore normal oxygenation. The randomized trial will test that hypothesis.

Timeline

Start

2010-06

Primary completion

2013-11

Completion

2013-11

Drugs

Indications