A Comparison of Pregabalin (Lyrica®) to Placebo in Pain Relief After Photorefractive Keratectomy (PRK) Surgery

Summary

The purpose of this study is to compare the efficacy of pregabalin to placebo for postoperative pain control after photorefractive keratectomy.

Timeline

Start

2010-03

Primary completion

2010-06

Completion

2010-06

Outcome

Missed primary endpoint

registry analysis (superiority test); Pregabalin vs Lactose Capsule; p = 0.180; ANOVA NCT01097577 ↗

paper There was no statistically significant difference in the primary outcome of 10% improvement in subjective pain scores between the treatment and placebo groups PMID 24914779 ↗

Publications

• Results Meek JM, Rosbolt MB, Taylor KR, Fusco EA, Panday VA, Reilly CD. Pregabalin versus placebo in postoperative pain relief of patients' status post photorefractive keratectomy: a double-masked, randomized, prospective study. J Ocul Pharmacol Ther. 2014 Sep;30(7):527-32. doi: 10.1089/jop.2013.0208. Epub 2014 Jun 10.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Pregabalin	Small molecule	75 mg	Oral

Indications

No indication recorded.