drugset / Trial / NCT01103154
A Trial of Nadolol Plus Isosorbide Mononitrate Versus Carvedilol for the Prevention of Variceal Rebleeding
Phase 4
Completed
121 enrolled
E-DA Hospital
National Science and Technology Council, Taiwan · collab
RandomizedParallel-groupOpen-labelPrevention
Summary
Carvedilol is shown to be superior to propranolol to reduce the portal pressure. This study was undertaken to compare the effectiveness and complication rates of nadolol and isosorbide mononitrate (ISMN) with carvedilol in the prevention of rebleeding from esophageal varices.
Timeline
- Start
- 2005-03
- Primary completion
- 2010-01
- Completion
- 2010-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Carvedilol | Other / unclassified | 6.25 mg | — |
| Comparator | Isosorbide Mononitrate | Other / unclassified | 10 mg | — |
| Comparator | Isosorbide Mononitrate | Other / unclassified | 20 mg | — |
| Comparator | Nadolol | Unknown | 40 mg | — |
| Comparator | Nadolol | Unknown | 80 mg | — |