drugset / Trial / NCT01109381

Safety and Efficacy Study of a Non-antibiotic Treatment for the Eradication of Helicobacter Pylori

NCT01109381

NaSingle-groupOpen-labelTreatment

Summary

At present, triple therapy is recommended by various guidelines for the treatment of Helicobacter pylori (H.pylori) infection. Recent studies have shown increasing resistance of H.pylori to commonly used antibiotics used in triple therapy. This study explores a non-antibiotic treatment regime for H.pylori that uses lauric acid as the primary anti-microbial agent. The study hypothesis is that Lauric acid works synergistically with omeprazole following administration of a mucolytic agent to kill H.pylori topically in the stomach.

Timeline

Start
2010-05
Primary completion
2011-12
Completion
2011-12

Drugs

EvaluationDrugModalityDoseRoute
Subject N-acetyl cysteine Unknown 1.2 g
Subject N-acetyl cysteine Unknown 2 g
Subject Omeprazole Other / unclassified 40 mg
Subject lauric acid Unknown 150 mg
Subject lauric acid Unknown 300 mg