drugset / Trial / NCT01123005
Imaging and Biomarkers of Hypoxia in Solid Tumors
Non-randomizedSequentialOpen-labelDiagnostic
Summary
Hypoxia, meaning a lack of oxygen, has been associated strongly with a wide range of human cancers. Hypoxia occurs when tumor growth exceeds the ability of blood vessels to supply the tumor with oxygenated blood. It is currently understood that hypoxic tumors are more aggressive. Current methods for measuring hypoxia include invasive procedures such as tissue biopsy, or insertion of an electrode into the tumor. EF5-PET may be a non-invasive way to measure tumor hypoxia.
Timeline
- Start
- 2010-12
- Primary completion
- 2015-08-21
- Completion
- 2015-08-21
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Carbogen | Other / unclassified | — | — |
| Subject | Dichloroacetate | Small molecule | — | — |
| Subject | EF5 | Diagnostic / imaging agent | 10 mbq | Intravenous |