drugset / Trial / NCT01123005

Imaging and Biomarkers of Hypoxia in Solid Tumors

NCT01123005

Phase 1 Terminated 28 enrolled Stanford University
Non-randomizedSequentialOpen-labelDiagnostic

Summary

Hypoxia, meaning a lack of oxygen, has been associated strongly with a wide range of human cancers. Hypoxia occurs when tumor growth exceeds the ability of blood vessels to supply the tumor with oxygenated blood. It is currently understood that hypoxic tumors are more aggressive. Current methods for measuring hypoxia include invasive procedures such as tissue biopsy, or insertion of an electrode into the tumor. EF5-PET may be a non-invasive way to measure tumor hypoxia.

Timeline

Start
2010-12
Primary completion
2015-08-21
Completion
2015-08-21

Drugs

EvaluationDrugModalityDoseRoute
Subject Carbogen Other / unclassified
Subject Dichloroacetate Small molecule
Subject EF5 Diagnostic / imaging agent 10 mbq Intravenous

Indications