Tamoxifen Citrate in Treating Patients With Metastatic or Recurrent Breast Cancer

Summary

RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using tamoxifen citrate may fight cancer by blocking the use of estrogen by tumor cells. PURPOSE: This phase II trial is studying how well tamoxifen citrate works in patients with metastatic or recurrent breast cancer.

Timeline

Start

2011-01-07

Primary completion

2020-11-30

Completion

2022-12

Publications

• Stearns V, ONeill A, Schneider BP, Skaar TC, Liu MC, Lohrisch C, Goetz MP, Vallejos CS, Sparano JA, Villa D, Silverman P, Cheema PS, Moore DF Jr, Sledge GW Jr. CYP2D6 activity in patients with metastatic breast cancer treated with single agent tamoxifen: results from ECOG-ACRIN E3108. Breast Cancer Res Treat. 2025 Feb;209(3):595-602. doi: 10.1007/s10549-024-07519-z. Epub 2024 Oct 21.

Drugs

Indications