drugset
drugset / Trial / NCT01128270

Pharmacotoxicology of Trichloroethylene Metabolites

NCT01128270 ↗

Phase 1/2 Completed 27 enrolled University of Florida National Institutes of Health (NIH) · collab
RandomizedFactorialOpen-labelBasic science

Summary

This is a research study to look at how Dichloroacetate (DCA), and investigational drug and chloral hydrate are broken down in the body. The purpose of the study is to better understand how humans metabolize these two common chemicals that are widely present in the environment. The study focuses on how the drug chloral hydrate is broken down and how it effects DCA

Timeline

Start
2010-04
Primary completion
2012-10
Completion
2012-10

Drugs

EvaluationDrugModalityDoseRoute
Subject Chloral Hydrate Small molecule 1.5 ug/kg Oral
Subject Chloral Hydrate Small molecule 25 mg/kg Oral
Subject DICHLOROACETIC ACID Small molecule 2.5 ug/kg Oral
Subject DICHLOROACETIC ACID Small molecule 25 mg/kg Oral

Indications

No indication recorded.