drugset / Trial / NCT01130077
A Pilot Study of Glioma Associated Antigen Vaccines in Conjunction with Poly-ICLC in Pediatric Gliomas
Phase 1
Completed
60 enrolled
James Felker
Connor's Cure · collabEllie Kavalieros Fund · collabTranslational Brain Tumor Research Fund · collab
NaSingle-groupOpen-labelTreatment
Summary
The overall objective of this pilot study is to collect immunological and safety data following administration of vaccinations with HLA-A2. This data will be used to decide whether a larger study of clinical efficacy is warranted.
Timeline
- Start
- 2009-02
- Primary completion
- 2024-11-01
- Completion
- 2024-11-01
Publications
- Pollack IF, Jakacki RI, Butterfield LH, Hamilton RL, Panigrahy A, Potter DM, Connelly AK, Dibridge SA, Whiteside TL, Okada H. Antigen-specific immune responses and clinical outcome after vaccination with glioma-associated antigen peptides and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in children with newly diagnosed malignant brainstem and nonbrainstem gliomas. J Clin Oncol. 2014 Jul 1;32(19):2050-8. doi: 10.1200/JCO.2013.54.0526. Epub 2014 Jun 2.
- Robison NJ, Kieran MW. Diffuse intrinsic pontine glioma: a reassessment. J Neurooncol. 2014 Aug;119(1):7-15. doi: 10.1007/s11060-014-1448-8. Epub 2014 May 3.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | HLA-A2 restricted glioma antigen peptides vaccine | Vaccine | — | Subcutaneous |
| Background | Hiltonol | Other / unclassified | — | Intramuscular |