The Effects of Antihypertensive Agents on Central Blood Pressure in Healthy Participants and Participants With Hypertension (MK-0000-166) (COMPLETED)
Summary
This study will test the relationship between CBP (central blood pressure) and PBP (peripheral blood pressure) effects after single and multiple doses of Isosorbide mononitrate extended release (ISMN ER) or Amlodipine besylate in participants with hypertension.
Timeline
- Start
- 2010-05
- Primary completion
- 2010-11
- Completion
- 2010-11
Outcome
Mixed primary results
registry analysis (superiority or other test); ISMN ER vs Placebo; p <0.0005; Mean Difference (Final Values) -13.1 (95% CI -15.3 to -10.9); ANOVA NCT01130168 ↗
registry analysis (superiority or other test); ISMN ER vs Placebo; p = 0.407; Mean Difference (Final Values) 1.3 (95% CI -1.7 to 4.3); ANOVA NCT01130168 ↗
registry analysis (superiority or other test); Amlodipine vs Placebo; p <0.0005; Mean Difference (Final Values) -5.9 (95% CI -8.9 to -2.9); ANOVA NCT01130168 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amlodipine | Other / unclassified | 10 mg | Oral |
| Subject | Isosorbide Mononitrate | Other / unclassified | 30 mg | Oral |