drugset / Trial / NCT01133821
Acute Psychotherapy for Bipolar II Depression
RandomizedParallel-groupTriple-blindTreatment
Summary
This proposed study is designed to compare the efficacy of interpersonal and social rhythm therapy (IPSRT) alone to IPSRT plus medication as an acute treatment for bipolar II depression. The investigators propose to conduct a randomized, controlled, trial comparing the effects of IPSRT plus pill placebo to IPSRT plus quetiapine on depressive symptoms in individuals suffering from Bipolar II depression. The investigators will also examine the impact of treatment on psychosocial function.
Timeline
- Start
- 2010-08
- Primary completion
- 2015-10
- Completion
- 2015-10
Publications
- Bailey BC, Early TJ, Williams-Sites KE, Dyson B, Swartz HA. Effects of Interpersonal and Social Rhythm Therapy on Suicidal Ideation in Adults With Bipolar II Depression. J Clin Psychiatry. 2025 Sep 29;86(4):24m15768. doi: 10.4088/JCP.24m15768.
- Swartz HA, Rucci P, Thase ME, Wallace M, Carretta E, Celedonia KL, Frank E. Psychotherapy Alone and Combined With Medication as Treatments for Bipolar II Depression: A Randomized Controlled Trial. J Clin Psychiatry. 2018 Mar/Apr;79(2):16m11027. doi: 10.4088/JCP.16m11027.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Quetiapine | Small molecule | 50 mg | — |
| Subject | Quetiapine | Small molecule | 100 mg | — |
| Subject | Quetiapine | Small molecule | 200 mg | — |