Pomalidomide for Cough in Patients With Idiopathic Pulmonary Fibrosis

Summary

The purpose of this study is to determine the safety and efficacy of pomalidomide over a 12 week duration in the treatment of chronic cough in patients with IPF as measured by a Cough Symptom Diary, Visual Analogue Scale for Cough Severity, Leicester Cough Questionnaire, St. George Respiratory Questionnaire, Cough-Specific Quality-of-Life Questionnaire, and adverse event reporting. There will be an option open to participants, who respond to treatment by meeting pre-determined criteria, to remain in the study for an additional 9 months or for a total of 54 weeks.

Timeline

Start

2010-04

Primary completion

2010-06

Completion

2010-06

Publications

• Background Horton MR, Danoff SK, Lechtzin N. Thalidomide inhibits the intractable cough of idiopathic pulmonary fibrosis. Thorax. 2008 Aug;63(8):749. doi: 10.1136/thx.2008.098699. No abstract available.

Drugs

Indications