drugset / Trial / NCT01142258
Trazodone for Sleep Disorders in Alzheimer's Disease
RandomizedParallel-groupTriple-blindTreatment
Summary
The purpose of this study is to determine whether trazodone is effective in the treatment of sleep disorders in Alzheimer's disease (AD).
Timeline
- Start
- 2010-03
- Primary completion
- 2012-04
- Completion
- 2012-08
Outcome
Met primary endpoint
paper trazodone users slept 42.5 more minutes per night and had their nighttime percent sleep increased 8.5 percentage points PMID 24495406 ↗
paper This study shows significant therapeutic effects of trazodone 50 mg in community-dwelling AD patients with SD. PMID 24495406 ↗
Publications
- McCleery J, Sharpley AL. Pharmacotherapies for sleep disturbances in dementia. Cochrane Database Syst Rev. 2020 Nov 15;11(11):CD009178. doi: 10.1002/14651858.CD009178.pub4.
- Camargos EF, Louzada LL, Quintas JL, Naves JO, Louzada FM, Nobrega OT. Trazodone improves sleep parameters in Alzheimer disease patients: a randomized, double-blind, and placebo-controlled study. Am J Geriatr Psychiatry. 2014 Dec;22(12):1565-74. doi: 10.1016/j.jagp.2013.12.174. Epub 2014 Jan 4.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Trazodone | Small molecule | 50 mg | — |