drugset / Trial / NCT01143025
Intraperitoneal Ropivacaine Nebulization for Pain Control After Laparoscopic Surgery
Phase 3
Completed
165 enrolled
San Gerardo Hospital
Azienda L'ULSS 15 Alta Padovana · collabAzienda U.S.L. della Valle d'Aosta, Ospedale Regionale Umberto Parini · collabFondazione IRCCS Policlinico San Matteo di Pavia · collabGruppo Ospedaliero San Donato, Policlinico San Pietro, Ponte San Pietro, Bergamo · collabUniversity of Milano Bicocca · collab
RandomizedParallel-groupTriple-blindTreatment
Summary
The purpose of this study is to assess if intraperitoneal nebulization of Ropivacaine 50 mg, 100 mg or 150 mg may prevent the use of morphine during the first day after laparoscopic cholecystectomy.
Timeline
- Start
- 2010-03
- Primary completion
- 2011-04
- Completion
- 2011-05
Publications
- Background Greib N, Schlotterbeck H, Dow WA, Joshi GP, Geny B, Diemunsch PA. An evaluation of gas humidifying devices as a means of intraperitoneal local anesthetic administration for laparoscopic surgery. Anesth Analg. 2008 Aug;107(2):549-51. doi: 10.1213/ane.0b013e318176fa1c.
- Background Schlotterbeck H, Schaeffer R, Dow WA, Diemunsch P. Cold nebulization used to prevent heat loss during laparoscopic surgery: an experimental study in pigs. Surg Endosc. 2008 Dec;22(12):2616-20. doi: 10.1007/s00464-008-9841-z. Epub 2008 Mar 18.
- Results Alkhamesi NA, Peck DH, Lomax D, Darzi AW. Intraperitoneal aerosolization of bupivacaine reduces postoperative pain in laparoscopic surgery: a randomized prospective controlled double-blinded clinical trial. Surg Endosc. 2007 Apr;21(4):602-6. doi: 10.1007/s00464-006-9087-6. Epub 2006 Dec 16.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Ropivacaine | Other / unclassified | 50 mg | Other |
| Comparator | Ropivacaine | Other / unclassified | 100 mg | Other |
| Comparator | Ropivacaine | Other / unclassified | 150 mg | Other |
Indications
No indication recorded.