Study Evaluating Effect of Esomeprazole, Omeprazole or Lansoprazole on the Pharmacodynamics (PD) and Pharmacokinetics (PK) of Clopidogrel

Phase 1 Completed 149 enrolled AstraZeneca

RandomizedCrossoverOpen-labelBasic science

Summary

The aim of this study is to determine if there is a pharmacological interaction between clopidogrel and different types of proton pump inhibitors (PPIs), and if the extent of this possible interaction would change over time.

Timeline

Start: 2010-05
Primary completion: 2011-05
Completion: 2011-05

Publications

Andersson T, Nagy P, Niazi M, Nylander S, Galbraith H, Ranjan S, Wallentin L. Effect of esomeprazole with/without acetylsalicylic acid, omeprazole and lansoprazole on pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteers. Am J Cardiovasc Drugs. 2014 Jun;14(3):217-27. doi: 10.1007/s40256-014-0073-4.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Clopidogrel	Small molecule	75 mg	—
Subject	Esomeprazole	Small molecule	40 mg	—
Subject	Lansoprazole	Other / unclassified	60 mg	—
Subject	Omeprazole	Other / unclassified	80 mg	—

Indications

No indication recorded.