Pharmacokinetics (PK) of Ertapenem Intravenous (IV) Bolus Versus Standard Infusion

Phase 4 Completed 12 enrolled Hartford Hospital Merck Sharp & Dohme LLC · collab

RandomizedCrossoverOpen-label

Summary

The purpose of this study is to characterize and compare the concentration-time profiles and multiple dose pharmacokinetics of a 5 minute intravenous (IV) bolus of ertapenem 1 gram daily versus the standard 30 minute infusion in healthy volunteers. Safety and tolerability and pharmacodynamic target attainment using Monte Carlo simulation will also be assessed and compared.

Timeline

Start: 2010-08
Primary completion: 2010-10
Completion: 2010-10

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Ertapenem	Small molecule	1 g	Intravenous

Indications

No indication recorded.