Estimation Of Effect Of Ketoconazole On Pharmacokinetics Of Crizotinib In Healthy Volunteers

Phase 1 Completed 15 enrolled Pfizer

Non-randomizedCrossoverOpen-label

Summary

The purpose of this study is to estimate the effect of multiple doses of ketoconazole on the single dose pharmacokinetics of crizotinib in healthy volunteers.

Timeline

Start: 2010-07
Primary completion: 2010-09
Completion: 2010-09

Publications

Xu H, O'Gorman M, Tan W, Brega N, Bello A. The effects of ketoconazole and rifampin on the single-dose pharmacokinetics of crizotinib in healthy subjects. Eur J Clin Pharmacol. 2015 Dec;71(12):1441-9. doi: 10.1007/s00228-015-1945-5. Epub 2015 Sep 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Crizotinib	Small molecule	150 mg	Oral
Subject	Ketoconazole	Small molecule	200 mg	Oral

Indications

No indication recorded.