drugset / Trial / NCT01156220
Investigation of Gender Specificity of the Effects of Furosemide in Healthy Female and Male Volunteers
RandomizedParallel-groupOpen-labelTreatment
Summary
In this study the gender specificity of the effects of furosemide in female and male volunteers will be investigated. The main objective is gender-specific comparison of the pharmacokinetic parameters of furosemide in relation to the effect of furosemide (urinary excretion). Secondary objectives are the gender-specific comparison of renal and systemic PAH clearance with the clearance of furosemide and the influence of various genetic polymorphisms on the variability of furosemide pharmacokinetics.
Timeline
- Start
- 2012-01
- Primary completion
- 2012-06
- Completion
- 2012-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Aminohippurate Sodium | Diagnostic / imaging agent | 500 mg | Other |
| Subject | Furosemide | Other / unclassified | 40 mg | Other |
Indications
No indication recorded.