Effect of Beta Blockade on Left Ventricular Remodeling and Function in Moderate to Severe Asymptomatic Aortic Regurgitation

Phase 4 Completed 75 enrolled Oslo University Hospital Haukeland University Hospital · collab University Ghent · collab University Hospital, Akershus · collab University Hospital, Gentofte, Copenhagen · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

The primary objective of this study is to evaluate the effect of beta-blocker on left ventricular (LV) remodeling in asymptomatic patients with moderate to severe aortic regurgitation.

Timeline

Start: 2010-08
Primary completion: 2014-08
Completion: 2014-09

Publications

Broch K, Urheim S, Lonnebakken MT, Stueflotten W, Massey R, Fossa K, Hopp E, Aakhus S, Gullestad L. Controlled release metoprolol for aortic regurgitation: a randomised clinical trial. Heart. 2016 Feb;102(3):191-7. doi: 10.1136/heartjnl-2015-308416. Epub 2015 Dec 9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Metoprolol	Other / unclassified	200 mg	—

Effect of Beta Blockade on Left Ventricular Remodeling and Function in Moderate to Severe Asymptomatic Aortic Regurgitation

Summary

Timeline

Publications

Drugs

Indications