drugset / Trial / NCT01158170

Prophylactic Cranial Irradiation in Erlotinib/Gefitinib-responders With Non-small Cell Lung Cancer (NSCLC) (RT1001)

NCT01158170

Phase 3 Unknown 200 enrolled Zhejiang Cancer Hospital
RandomizedParallel-groupOpen-labelPrevention

Summary

RATIONALE: Radiation therapy to the brain may be effective in preventing brain metastases in patients with advanced non-small cell lung cancer. It is not yet known whether radiation therapy is more effective than observation in patients with advanced non-small cell lung cancer. PURPOSE: This randomized phase III trial is studying radiation therapy to the brain to see how well it works compared with observation in preventing brain metastases in patients with advanced non-small cell lung cancer

Timeline

Start
2010-06
Primary completion
2013-05
Completion
2013-12

Drugs

EvaluationDrugModalityDoseRoute
Background Erlotinib Small molecule 150 mg
Background Gefitinib Small molecule 250 mg