A Study of Postprandial Hyperglycemia in Participants With Type 2 Diabetes

Summary

This Study is looking at whether high blood glucose levels after a meal affect arterial stiffness more or less than low blood glucose levels, and whether certain cardiovascular markers influence the outcome of this.

Timeline

Start

2010-10

Primary completion

2013-02

Completion

2013-02

Outcome

Missed primary endpoint

registry p = 0.617; LS mean difference 0.26 (95% CI -0.78 to 1.30) NCT01159938 ↗

registry p = 0.676; LS Mean Difference -0.19 (95% CI -1.10 to 0.72) NCT01159938 ↗

registry p = 0.724; LS Mean Difference 0.20 (95% CI -0.94 to 1.34) NCT01159938 ↗

registry p = 0.466; LS Mean Difference -0.29 (95% CI -1.09 to 0.51) NCT01159938 ↗

registry p = 0.275; LS Mean Difference -0.48 (95% CI -1.36 to 0.40) NCT01159938 ↗

Publications

• Gordin D, Saraheimo M, Tuomikangas J, Soro-Paavonen A, Forsblom C, Paavonen K, Steckel-Hamann B, Harjutsalo V, Nicolaou L, Pavo I, Koivisto V, Groop PH. Insulin exposure mitigates the increase of arterial stiffness in patients with type 2 diabetes and albuminuria: an exploratory analysis. Acta Diabetol. 2019 Nov;56(11):1169-1175. doi: 10.1007/s00592-019-01351-4. Epub 2019 May 22.
• Gordin D, Saraheimo M, Tuomikangas J, Soro-Paavonen A, Forsblom C, Paavonen K, Steckel-Hamann B, Vandenhende F, Nicolaou L, Pavo I, Koivisto V, Groop PH. Influence of Postprandial Hyperglycemic Conditions on Arterial Stiffness in Patients With Type 2 Diabetes. J Clin Endocrinol Metab. 2016 Mar;101(3):1134-43. doi: 10.1210/jc.2015-3635. Epub 2016 Jan 5.
• Muka T, de Jonge EA, Kiefte-de Jong JC, Uitterlinden AG, Hofman A, Dehghan A, Zillikens MC, Franco OH, Rivadeneira F. The Influence of Serum Uric Acid on Bone Mineral Density, Hip Geometry, and Fracture Risk: The Rotterdam Study. J Clin Endocrinol Metab. 2016 Mar;101(3):1113-22. doi: 10.1210/jc.2015-2446. Epub 2015 Dec 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Insulin Lispro	Protein / enzyme biologic	—	Subcutaneous

Indications