drugset / Trial / NCT01160263
Study of Dopamine and Serotonin Transporters in Patients With Amyotrophic Lateral Sclerosis and Controls
Phase 3
Completed
16 enrolled
Assistance Publique - Hôpitaux de Paris
ARS (Association pour la Recherche sur la Sclérose Latérale Amyotrophique) · collabAgence Générale des Equipements et Produits de Santé · collabAssociation Française contre les Myopathies (AFM), Paris · collab
Non-randomizedParallel-groupOpen-labelDiagnostic
Summary
The purpose of this study is to study the transporters of serotonin and dopamine in ALS patients in relation with the clinical phenotype, i.e., patients without stiffness, patients with pyramidal stiffness, patients with mixed (pyramidal and extra pyramidal) stiffness. For such a goal the investigators will use SPECT to compare the binding of two specific tracers in ALS patients and in matched healthy controls.
Timeline
- Start
- 2012-10
- Primary completion
- 2014-10
- Completion
- 2014-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | 123I-ADAM | Unknown | 5 ml | Intravenous |
| Subject | 123I-ADAM | Unknown | 185 mbq | Intravenous |
| Subject | ioflupane 123I | Unknown | 2.5 ml | Intravenous |
| Subject | ioflupane 123I | Unknown | 185 mbq | Intravenous |