drugset / Trial / NCT01160276
Drug Interaction Between Colchicine and Calcineurin Inhibitors in Renal Graft Recipients
Phase 1
Completed
17 enrolled
Assistance Publique - Hôpitaux de Paris
Institut National de la Santé Et de la Recherche Médicale, France · collab
Non-randomizedParallel-groupOpen-labelTreatment
Summary
Ciclosporin inhibits P-glycoprotein should increase colchicine bioavailability whereas tacrolimus should not influence colchicine disposition. This is a prospective, controlled, open labeled study performed in renal graft recipients comparing colchicine single dose (1mg) pharmacokinetics in 14 patients treated with tacrolimus and 14 patients treated with cyclosporin.
Timeline
- Start
- 2010-05
- Primary completion
- 2012-01
- Completion
- 2012-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Colchicine | Small molecule | 1 mg | — |
| Comparator | Cyclosporine | Peptide | — | — |
| Comparator | Tacrolimus | Small molecule | — | — |
Indications
No indication recorded.