Parenteral Nutrition With Intravenous and Oral Fish Oil for Intensive Care Patients

Summary

The primary objective is to assess the effect of fish oil-enriched enteral and parenteral nutrition on blood oxygenation in critically ill patients.

Timeline

Start

2013-05

Primary completion

2017-11

Completion

2017-11

Outcome

Missed primary endpoint

paper Blood oxygenation (ΔPaO2/FiO2 from D1 to D4: -1.3 ± 83.7, n = 42, and 13.3 ± 86.1, n = 39, in omega-3 and control group, respectively, p = 0.7795 PMID 33932802 ↗

paper Enteral and supplemental PN both enriched with omega-3 PUFA did not improve lung function PMID 33932802 ↗

Publications

• Singer P, Bendavid I, Mesilati-Stahy R, Green P, Rigler M, Lev S, Schif-Zuck S, Amiram A, Theilla M, Kagan I. Enteral and supplemental parenteral nutrition enriched with omega-3 polyunsaturated fatty acids in intensive care patients - A randomized, controlled, double-blind clinical trial. Clin Nutr. 2021 May;40(5):2544-2554. doi: 10.1016/j.clnu.2021.03.034. Epub 2021 Apr 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Nutriflex Lipid special	Unknown	—	—
Subject	Nutriflex Omega special	Unknown	—	—
Subject	Oxepa	Unknown	—	—
Comparator	Pulmocare	Unknown	—	—

Indications

No indication recorded.