Investigation of the Efficacy of Antibiotics on Pulmonary Sarcoidosis

Phase 1 Completed 15 enrolled Vanderbilt University

NaSingle-groupOpen-labelDiagnostic

Summary

Sarcoidosis is a granulomatous disease for which the molecular and immunologic association with mycobacteria continues to strengthen. The investigators are interested in conducting a proof-of-concept investigation of the effects of antibiotics on sarcoidosis resolution. The investigators hypothesize that pulmonary sarcoidosis will improve faster if patients are given antimycobacterial therapy, in addition to their standard therapy.

Timeline

Start: 2010-07
Primary completion: 2010-11
Completion: 2010-11

Publications

Drake WP, Richmond BW, Oswald-Richter K, Yu C, Isom JM, Worrell JA, Shipley GR. Effects of broad-spectrum antimycobacterial therapy on chronic pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2013 Nov 25;30(3):201-11.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Azithromycin	Small molecule	250 mg	Oral
Comparator	Ethambutol	Small molecule	15 mg/kg	Oral
Comparator	Ethambutol	Small molecule	25 mg/kg	Oral
Comparator	Levofloxacin	Small molecule	500 mg	Oral
Comparator	Rifabutin	Small molecule	10 mg/kg	Oral
Comparator	Rifampin	Small molecule	10 mg/kg	Oral

Investigation of the Efficacy of Antibiotics on Pulmonary Sarcoidosis

Summary

Timeline

Publications

Drugs

Indications