Treatment of Apathy in Alzheimer's Disease With Modafinil

Phase 3 Completed 22 enrolled Brown University Cephalon · collab National Institute of Mental Health (NIMH) · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

This study examined the effects of modafinil on apathetic symptomatology, performance of activities of daily living (ADLs) and caregiver burden in individuals with Alzheimer's disease (AD).

Timeline

Start: 2005-07
Primary completion: —
Completion: 2007-09

Publications

Frakey LL, Salloway S, Buelow M, Malloy P. A randomized, double-blind, placebo-controlled trial of modafinil for the treatment of apathy in individuals with mild-to-moderate Alzheimer's disease. J Clin Psychiatry. 2012 Jun;73(6):796-801. doi: 10.4088/JCP.10m06708. Epub 2012 May 15.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Modafinil	Small molecule	200 mg	—

Treatment of Apathy in Alzheimer's Disease With Modafinil

Summary

Timeline

Publications

Drugs

Indications