Comparison of Triflusal and Clopidogrel in Secondary Prevention of Stroke Based on the Genotyping

Phase 4 Completed 795 enrolled Gangnam Severance Hospital Myung In Pharmaceutical Company · collab Yonsei University · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to compare the preventive effect of stroke between triflusal and clopidogrel in ischemic stroke patient based on the cytochrome P450 2C19 (CYP2C19) polymorphism.

Timeline

Start: 2010-03
Primary completion: 2014-12
Completion: 2015-03

Publications

Han SW, Kim YJ, Ahn SH, Seo WK, Yu S, Oh SH, Kim YN, Lee KY; MAESTRO Study Investigators. Protocol for the comparison of triflusal and clopidogrel in secondary prevention of stroke based on cytochrome P450 2C19 genotyping (MASETRO study): A multicenter, randomized, open-label, parallel-group trial. Int J Stroke. 2016 Jun;11(4):485-91. doi: 10.1177/1747493015620804. Epub 2016 Jan 5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Clopidogrel	Small molecule	75 mg	Oral
Subject	Triflusal	Small molecule	300 mg	Oral

Comparison of Triflusal and Clopidogrel in Secondary Prevention of Stroke Based on the Genotyping

Summary

Timeline

Publications

Drugs

Indications