S-1 and Radiotherapy in Elderly Patients With Esophageal Cancer

Phase 1 Completed 12 enrolled Zhejiang Cancer Hospital

Non-randomizedSingle-groupOpen-labelTreatment

Summary

Elderly patients with esophageal cancer will receive thoracic radiation therapy 54Gy over 30 fractions, and concurrent with s-1 on days 1-14 and 29-42 at the following dosages: 60, 70, and 80 mg/m(2)/day.

Timeline

Start: 2010-02
Primary completion: 2011-12
Completion: 2011-12

Publications

Ji Y, Qiu G, Sheng L, Sun X, Zheng Y, Chen M, Du X. A phase I dose escalation study of S-1 with concurrent radiotherapy in elderly patients with esophageal cancer. J Thorac Dis. 2016 Mar;8(3):451-8. doi: 10.21037/jtd.2016.02.70.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	S-1	Small molecule	60 mg/m2	Oral
Subject	S-1	Small molecule	70 mg/m2	Oral
Subject	S-1	Small molecule	80 mg/m2	Oral

S-1 and Radiotherapy in Elderly Patients With Esophageal Cancer

Summary

Timeline

Publications

Drugs

Indications