Intraocular Pressure and Ocular Perfusion Pressure of Cosopt in Normal Tension Glaucoma

Summary

To prove the non-inferiority of the fixed timolol-dorzolamide combination (Cosopt) compared to 0.005% latanoprost (Xalatan) in the aspects of intraocular pressure (IOP) and ocular perfusion pressure (OPP) in subjects with normal tension glaucoma (NTG) Clinical hypotheses. Primary hypothesis * Cosopt group is non-inferior to Xalatan group in diurnal IOP reduction. Secondary hypothesis * Cosopt group is non-inferior to Xalatan group in diurnal diastolic and systolic OPP.

Timeline

Start

2011-03

Primary completion

2014-10

Completion

2014-10

Publications

• Lee NY, Park HY, Park CK. Comparison of the Effects of Dorzolamide/Timolol Fixed Combination versus Latanoprost on Intraocular Pressure and Ocular Perfusion Pressure in Patients with Normal-Tension Glaucoma: A Randomized, Crossover Clinical Trial. PLoS One. 2016 Jan 12;11(1):e0146680. doi: 10.1371/journal.pone.0146680. eCollection 2016.

Drugs

Indications