Intact Vagal Innervation for and Glucagon-like Peptide-1 (GLP-1) Effects

Unknown 30 enrolled University Hospital, Gentofte, Copenhagen University of Copenhagen · collab

Non-randomizedParallel-groupOpen-labelBasic science

Summary

The aim of this study is to investigate the role of transmission via the vagal nerve for the effect of glucose and Glucagon-like peptide-1 (GLP-1) in respect to insulin secretion. The hypothesis is that a great deal of the effects of GLP-1 is mediated via the nervous system and for this reason the investigators will research individuals with and without intact nervous supply.

Timeline

Start: 2009-08
Primary completion: 2011-10
Completion: 2012-12

Publications

Plamboeck A, Veedfald S, Deacon CF, Hartmann B, Wettergren A, Svendsen LB, Meisner S, Hovendal C, Knop FK, Vilsboll T, Holst JJ. Characterisation of oral and i.v. glucose handling in truncally vagotomised subjects with pyloroplasty. Eur J Endocrinol. 2013 Jul 6;169(2):187-201. doi: 10.1530/EJE-13-0264. Print 2013 Aug.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Vildagliptin	Other / unclassified	50 mg	—

Indications

No indication recorded.