The Effects of Cannabidiol and ∆-9-THC in Humans

Phase 0 Completed 27 enrolled Yale University

RandomizedCrossoverQuadruple-blindBasic science

Summary

Cannabis is the most commonly used illicit substance in the US and herbal cannabis consists of a number of cannabinoids including Δ-9 THC and CBD. This study will characterize the interactive effects of the two major components of cannabis i.e. Δ-9-THC and CBD.

Timeline

Start: 2010-02-01
Primary completion: 2014-10-06
Completion: 2014-10-06

Publications

Ganesh S, Cortes-Briones J, Schnakenberg Martin AM, Skosnik PD, D'Souza DC, Ranganathan M. Delta-9-Tetrahydrocannabinol, Cannabidiol, and Acute Psychotomimetic States: A Balancing Act of the Principal Phyto-Cannabinoids on Human Brain and Behavior. Cannabis Cannabinoid Res. 2023 Oct;8(5):846-856. doi: 10.1089/can.2021.0166. Epub 2022 Mar 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cannabidiol	Other / unclassified	5 mg	—
Subject	Dronabinol	Other / unclassified	0.035 mg/kg	Intravenous

Indications

No indication recorded.