Trial of Induction Chemotherapy With Carboplatin and Paclitaxel, Followed by Concurrent Chemotherapy/Radiation Therapy With ZD1839 (IRESSA), 5-FU, Hydroxyurea, and Twice-Daily Radiation, Followed by Adjuvant ZD1839 Monotherapy in Patients With Locally Advanced Head & Neck Cancer

Summary

The purpose of this study is to explore the activity of ZD1839 added to concurrent chemoradiotherapy and as adjuvant monotherapy in patients with locally advanced head and neck cancer. Activity is described in terms of response rate (complete responses only).

Timeline

Start

2003-01-27

Primary completion

2018-07

Completion

2018-08

Outcome

Met primary endpoint

registry p < 0.01; proportion 0.88 (95% CI 0.77 to 0.95) NCT01185171 ↗

Drugs

Indications