Levothyroxine (L-T4) Absorption After Bariatric Surgery

Summary

Intestinal absorption of levothyroxine (LT4) tablets depends on its dissolution in gastric acid secretion, which is reduced after bariatric interventions. Impaired LT4 absorption due to low gastric dissolution has been reported in patients with atrophic or chronic gastritis. The objective of this study is to evaluate the absorption of LT4 tablets in morbidly obese patients before and after Roux-en-Y bariatric surgery.

Timeline

Start

2007-09

Primary completion

2010-07

Completion

2010-07

Publications

• Background Sherman SI, Malecha SE. Absorption and Malabsorption of Levothyroxine Sodium. Am J Ther. 1995 Oct;2(10):814-818. doi: 10.1097/00045391-199510000-00014. No abstract available.

Drugs

Indications