Loxapine in the Management of Restlessness During Mechanical Ventilation Weaning

Summary

This study aims to assess the efficacy of a drug (loxapine, a neuroleptic) in calming patients down in a situation of restlessness during mechanical ventilation weaning. This drug is used for several years to quieten restless patients. Its purpose is to restore spontaneous breathing sooner and therefore to reduce the risks of intubation and mechanical ventilation.

Timeline

Start

2011-05

Primary completion

2014-05

Completion

2014-07

Outcome

Missed primary endpoint

paper Median times to successful extubation were 3.2 days in the loxapine group and 5 days in the placebo group (relative risk 1.2, 95% CI 0.75-1.88, p = 0.45). PMID 28877705 ↗

paper In this prematurely stopped trial, loxapine did not significantly shorten weaning from MV. PMID 28877705 ↗

Publications

• Gaudry S, Sztrymf B, Sonneville R, Megarbane B, Van Der Meersch G, Vodovar D, Cohen Y, Ricard JD, Hajage D, Salomon L, Dreyfuss D. Loxapine to control agitation during weaning from mechanical ventilation. Crit Care. 2017 Sep 6;21(1):235. doi: 10.1186/s13054-017-1822-y.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	loxapine	Small molecule	100 mg	Other

Indications

No indication recorded.