A Pilot Study of Radiation-Immune Cell Combination Therapy in Cervical Cancer

Summary

Among the immune cell therapy, autologous adoptive immune cell therapy is a method to transfer the immune cells derived from peripheral white blood cells and expanded and stimulated with various cytokines and tumor specific antigens in cancer patients. Recently, the low-dose radiation is known to increase the immune response in many human cancer patients. In a clinical trial, 70% response rate with combination of low-dose radiation and adoptive immune cell therapy was reported in recurrent melanoma patients. This study is to investigate the feasibility of combination of low-dose radiation and autologous immune cell therapy in recurrent cervical cancer which is resistant to conventional palliative treatment.

Timeline

Start

2010-09

Primary completion

2011-09

Completion

2012-04

Outcome

Outcome not reported

Stopped (Enrollment): “No further enrollment after two patients”

Drugs

Indications