The Effects of Amiloride and Spironolactone on Renophysiological and Cardiovascular Variables

Summary

The investigators wish to study the effect of retaining potassium. The participants have essential hypertension. The test substances are Amiloride, Spironolactone and placebo. The participants will ingest tablets for 28 days before being examined. We will perform a 24 hours urine collection, 24-hours bloodpressure measurement, blood and urine samples and we also examine the patient using a SphygmoCor.

Timeline

Start

2010-08

Primary completion

2015-08

Completion

2015-08

Drugs

Indications