drugset / Trial / NCT01204099

Study of PX-866 and Docetaxel in Solid Tumors

NCT01204099

Phase 1/2 Completed 223 enrolled Cascadian Therapeutics Inc.
RandomizedParallel-groupOpen-labelTreatment

Summary

Phase 1: To determine the maximally tolerated dose (MTD) or recommended dose (RD) and any potential efficacy of PX-866 in combination with docetaxel in patients with solid tumors. Phase 2: To determine the antitumor activity and safety of PX-866 in combination with docetaxel versus docetaxel alone in patients with NSCLC or SCCHN.

Timeline

Start
2010-09
Primary completion
2013-12
Completion
2014-02

Drugs

EvaluationDrugModalityDoseRoute
Subject SONOLISIB Small molecule 8 mg Oral
Background Docetaxel Small molecule 75 mg/m2 Intravenous